Abstract:
According to traditional usage, the extract of Longan Arillus was tested
for its anxiolytic-like effect by application of the Vogel-type anti-conflict
method in mice. The extract indicated significant activity at a dose of 2
g/kg, s.c., and results of the bioassay-oriented
isolation revealed adenosine to be the active principle. Adenosine produced
the anti-conflict effect significantly at a dose of 30 mg/kg,
s.c. Adenine, uridine, and 5-methyluridine did not exhibit the effect,
although these compounds were isolated from the extract. Some other related
compounds such as AMP and c-AMP showed no effect, except for inosine. Adenosine
also contributed to the analgesic effect which was observed in the extract
by the writhing method.
Key words:
Longan Arillus -
Euphoria longana
- Sapindaceae - adenosine - anti-anxiety - analgesia
1 This paper is dedicated to the memory of the late Professor George Büchl.
